Neuropeptide Y is a 36-amino acid neuropeptide that is among the most abundant peptides in the mammalian nervous system. It plays central roles in appetite regulation, stress response, anxiety modulation, and circadian rhythm maintenance. Research interest spans from obesity (as the brain’s primary hunger signal) to military stress resilience and PTSD treatment.
Dosage Information (Research Use)
Intranasal: 2.4-9.6mg per dose in human studies. Research typically uses central injection in animal models. Research compound only.
Reconstitution & Handling
Reconstitute in sterile saline. Sensitive to proteolysis — handle carefully.
Half-Life & Pharmacokinetics
20-30 minutes (plasma)
Reported Observations in Literature
Increased appetite is the primary expected effect. Potential cardiovascular effects (vasoconstriction). Sedation at high doses. Anxiety reduction in stressed subjects.
Key Research References
- Morgan CA et al. “Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress.” Biol Psychiatry. 2002;52:136-42
- Sah R et al. “Neuropeptide Y and posttraumatic stress disorder.” Mol Psychiatry. 2009;14:954-8