Epithalon (also spelled Epitalon) is a synthetic version of a naturally occurring pineal gland peptide called epithalamin. It has become a focal point in longevity and anti-aging research due to its documented ability to activate telomerase in human somatic cells.
Research Applications
Telomerase activation research, telomere length studies, circadian rhythm/melatonin regulation, retinal degeneration models, and lifespan extension research in animal models.
Dosage Information (Research Use)
Research protocols: 5-10 mg/day subcutaneously for 10-20 day courses, repeated 2-3 times annually. Research use only.
Reconstitution & Handling
Standard BAC water reconstitution. Small peptide dissolves quickly.
Half-Life & Pharmacokinetics
Short plasma half-life typical of tetrapeptides, but telomerase activation effects are sustained, supporting cycled course-based protocols rather than continuous use.
Reported Observations in Literature
Published research reports minimal adverse effects. The short course-based protocol limits potential for chronic administration effects.
Key Research References
- Khavinson VK, et al. “Peptide Epitalon activates chromatin at the old age.” Neuro Endocrinol Lett. 2003
- Anisimov VN, et al. “Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.” Biogerontology. 2003