Recovery ⏱ Half-life: Approximately 1-2 minutes in plasma. Tissue-level effects persist longer.

VIP

VIP (Vasoactive Intestinal Peptide)

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Half-Life
Approximately 1-2 minutes in plasma. Tissue-level effects persist longer.
Mol. Weight
3326.82 g/mol

What is VIP?

VIP is a naturally occurring neuropeptide with remarkably broad physiological effects — from vasodilation and bronchodilation to immune regulation and neuroprotection. Its anti-inflammatory potency has made it a focus in chronic inflammatory condition research.

Research Applications

CIRS/biotoxin illness, pulmonary hypertension, autoimmune modulation, GI motility, neuroprotection, and circadian rhythm regulation.

Dosage Information (Research Use)

Intranasal: 50 mcg per nostril, 1-4 times daily. Subcutaneous and IV protocols also documented. Research use only.

Reconstitution & Handling

Standard BAC water for injection. Nasal spray protocols use preserved saline.

Half-Life & Pharmacokinetics

Approximately 1-2 minutes in plasma. Tissue-level effects persist longer.

Reported Observations in Literature

Vasodilation effects: hypotension, facial flushing, diarrhea. Nasal route reduces systemic effects.

Key Research References

  • Gonzalez-Rey E, et al. “Vasoactive intestinal peptide: a first-class immune regulator.” Ann N Y Acad Sci. 2007

How VIP Works

VIP is a 28-amino acid neuropeptide that acts on VPAC1 and VPAC2 receptors. It induces smooth muscle relaxation, vasodilation, and has potent anti-inflammatory effects by inhibiting TNF-α, IL-6, and other pro-inflammatory cytokines. Additionally modulates regulatory T-cell function.

Research Findings

Studied for CIRS (Chronic Inflammatory Response Syndrome), mold illness protocols, pulmonary arterial hypertension, and autoimmune conditions. Intranasal administration is common in clinical research.

Dosage & Administration

Intranasal: 50 mcg per nostril, 1-4 times daily. Subcutaneous and IV protocols also documented. Research use only.

Safety & Side Effects

Vasodilation effects: hypotension, facial flushing, diarrhea. Nasal route reduces systemic effects.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Molecular Weight 3326.82 g/mol
Half-Life Approximately 1-2 minutes in plasma. Tissue-level effects persist longer.
Available Sizes 5mg
Storage Lyophilized: -20°C. Reconstituted: 2-8°C.

Key Research References

  • Gonzalez-Rey E, et al. "Vasoactive intestinal peptide: a first-class immune regulator." Ann N Y Acad Sci. 2007

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