Cognitive ⏱ Half-life: Short plasma half-life typical of tripeptides. Experimental

Pinealon

Pinealon (EDR Peptide)

Updated March 15, 2026
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Evidence at a Glance

Regulatory statusExperimental
Russian Khavinson bioregulator (EDR tripeptide); no Western approval or human trials
Human evidenceNone
Animal evidenceLimited

Pinealon (Glu-Asp-Arg) is a Khavinson-group short-peptide bioregulator whose neuroprotective claims rest almost entirely on in-vitro and rodent studies from a single Russian research lineage, with no rigorous peer-reviewed human trials.

What the research does not support

  • It is not approved by the FDA or EMA and has no verified human clinical trial establishing efficacy or safety.
  • The proposed mechanism of binding DNA to regulate gene expression is a hypothesis, not an established fact.
  • Nearly all supporting evidence originates from the same St. Petersburg group, so results have not been independently replicated.
  • It has not been shown to slow aging, reverse cognitive decline, or treat any neurological disease in humans.
Half-Life
Short plasma half-life typical of tripeptides.
Mol. Weight
375.38 g/mol

What is Pinealon?

Pinealon is a synthetic tripeptide designed to support pineal gland function and protect neural tissue from oxidative stress. Its small size allows blood-brain barrier penetration, enabling direct CNS effects.

Research Applications

Neuroprotection, pineal function support, melatonin pathway modulation, sleep research, and cognitive aging models.

Dosage Information (Research Use)

Research protocols: 10-20 mg/day orally or subcutaneously for 10-30 day courses. Research use only.

Reconstitution & Handling

Standard BAC water for injection. Also available in capsule form for oral research.

Half-Life & Pharmacokinetics

Short plasma half-life typical of tripeptides.

Reported Observations in Literature

Generally well-tolerated in published research. No significant adverse effects reported.

Key Research References

  • Khavinson VK. “Peptides and Ageing.” Neuro Endocrinol Lett. 2002

How Pinealon Works

Pinealon is a synthetic tripeptide studied for its effects on pineal gland function and neural tissue protection. It modulates antioxidant enzyme expression, supports melatonin synthesis pathways, and has shown neuroprotective effects in oxidative stress models. As a small tripeptide, it can cross the blood-brain barrier.

Research Findings

Part of the Khavinson peptide bioregulator series from Russian research tradition. Studied for sleep quality improvement, cognitive support in aging models, and neural tissue protection against oxidative damage.

Dosage & Administration

Research protocols: 10-20 mg/day orally or subcutaneously for 10-30 day courses. Research use only.

Safety & Side Effects

Generally well-tolerated in published research. No significant adverse effects reported.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence Glu-Asp-Arg
Molecular Weight 375.38 g/mol
Half-Life Short plasma half-life typical of tripeptides.
Available Sizes 5mg, 10mg
Storage Lyophilized: -20°C. Reconstituted: 2-8°C.

Key Research References

  • Khavinson VK. "Peptides and Ageing." Neuro Endocrinol Lett. 2002

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