Humanin was the first mitochondrial-derived peptide (MDP) discovered, originally identified for its ability to protect neurons against Alzheimer’s-related toxicity. It has since been found to have broad cytoprotective effects across multiple organ systems.
Research Applications
Alzheimer’s disease neuroprotection, mitochondrial biology, cellular stress resistance, metabolic regulation, and aging/longevity research.
Dosage Information (Research Use)
Research protocols vary widely. Animal studies: 0.4-40 mcg/g IP. Analogs like HNG (S14G-Humanin) are 1000x more potent. Research use only.
Reconstitution & Handling
Standard BAC water reconstitution.
Half-Life & Pharmacokinetics
Not well characterized in published pharmacokinetic data.
Reported Observations in Literature
Generally well-tolerated in animal studies. No significant toxicity reported at research doses.
Key Research References
- Hashimoto Y, et al. “A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer’s disease genes and Aβ.” Proc Natl Acad Sci. 2001