Dihexa is one of the most potent synaptogenic compounds ever identified in research — an orally bioavailable peptidomimetic that promotes new synapse formation through the HGF/c-Met pathway at concentrations millions of times lower than traditional neurotrophic factors.
Research Applications
Synaptogenesis research, cognitive restoration models, HGF/c-Met signaling, Alzheimer’s disease models, and neurotrophic factor pharmacology.
Dosage Information (Research Use)
Animal research: 0.25-2 mg/kg oral or IP. Human dosing not established. Extreme potency requires careful protocol design. Research use only.
Reconstitution & Handling
Orally bioavailable — typically supplied as capsules or powder for oral administration. Can also be dissolved in DMSO for research injection protocols.
Half-Life & Pharmacokinetics
Not fully characterized. Oral bioavailability confirmed in animal models.
Reported Observations in Literature
No published toxicity data in animals at research doses. Theoretical concern about c-Met pathway activation and cell proliferation — not confirmed in published data. No human safety data exists.
Key Research References
- McCoy AT, et al. “Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.” J Pharmacol Exp Ther. 2013