Longevity ⏱ Half-life: ~10-15 minutes (IV); intracellular: 2-3 hours

Glutathione

L-Glutathione (γ-L-Glutamyl-L-Cysteinyl-Glycine)

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Half-Life
~10-15 minutes (IV); intracellular: 2-3 hours
Purity
≥98% (reduced form, GSH)
Mol. Weight
307.32 Da
Form
Lyophilized powder, oral capsules, liposomal, IV solution

What is Glutathione?

Glutathione is a naturally occurring tripeptide found in every cell of the body, with the highest concentrations in the liver. It is the master regulator of the cellular antioxidant defense system and plays essential roles in immune function, detoxification, and protein synthesis. Declining glutathione levels are associated with aging and nearly every chronic disease studied.

Dosage Information (Research Use)

IV: 600-2400mg per infusion, 1-3x weekly. Oral: 250-1000mg daily (liposomal preferred). SubQ: 200-600mg, 2-3x weekly. Multiple administration routes under research.

Reconstitution & Handling

IV/SubQ: reconstitute lyophilized powder in sterile water. Light-sensitive — prepare immediately before use.

Half-Life & Pharmacokinetics

~10-15 minutes (IV); intracellular: 2-3 hours

Reported Observations in Literature

Generally well tolerated. IV administration may cause bloating, cramping, or allergic reactions in rare cases. Oral supplementation occasionally causes GI discomfort. Caution in patients taking cisplatin or other chemotherapy agents (may reduce drug efficacy).

Key Research References

  • Forman HJ et al. “Glutathione: overview of its protective roles.” Mol Aspects Med. 2009;30:1-12
  • Richie JP et al. “Randomized controlled trial of oral glutathione supplementation on body stores.” Eur J Nutr. 2015;54:251-63

How Glutathione Works

Glutathione is the most abundant intracellular antioxidant, present in millimolar concentrations. It neutralizes reactive oxygen species (ROS) through its thiol group, serves as a cofactor for glutathione peroxidase enzymes, conjugates with xenobiotics for Phase II detoxification, and maintains other antioxidants (vitamins C and E) in their reduced forms. The GSH:GSSG ratio is a critical marker of cellular redox status.

Research Applications

🔬 Oxidative stress and aging
🔬 Neurodegenerative diseases
🔬 Liver disease and detoxification

Research Findings

Glutathione levels decline with age, correlating with increased oxidative damage. IV glutathione has shown benefit in Parkinson's disease pilot studies. Oral bioavailability is poor; liposomal and sublingual forms show improved absorption. N-acetylcysteine (NAC) is commonly used as a GSH precursor with better oral bioavailability.

Dosage & Administration

IV: 600-2400mg per infusion, 1-3x weekly. Oral: 250-1000mg daily (liposomal preferred). SubQ: 200-600mg, 2-3x weekly. Multiple administration routes under research.

Safety & Side Effects

Generally well tolerated. IV administration may cause bloating, cramping, or allergic reactions in rare cases. Oral supplementation occasionally causes GI discomfort. Caution in patients taking cisplatin or other chemotherapy agents (may reduce drug efficacy).

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence γ-Glu-Cys-Gly
Molecular Weight 307.32 Da
Half-Life ~10-15 minutes (IV); intracellular: 2-3 hours
Purity ≥98% (reduced form, GSH)
Form Lyophilized powder, oral capsules, liposomal, IV solution
Storage Lyophilized: -20°C, protect from light. Solution: use immediately.

Key Research References

  • Forman HJ et al. "Glutathione: overview of its protective roles." Mol Aspects Med. 2009;30:1-12
  • Richie JP et al. "Randomized controlled trial of oral glutathione supplementation on body stores." Eur J Nutr. 2015;54:251-63

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