LL-37 is the sole member of the cathelicidin family of host defense peptides in humans. It serves as a critical first-line defense component of the innate immune system, with activity spanning antimicrobial defense, immune regulation, and tissue repair.
Research Applications
Antimicrobial defense research, wound healing, biofilm disruption, innate immunity studies, and vitamin D-immune axis research.
Dosage Information (Research Use)
Research protocols vary widely by application. Topical, subcutaneous, and in vitro concentrations documented in literature. Research use only.
Reconstitution & Handling
Standard BAC water reconstitution. Store carefully — larger peptide with potential for aggregation.
Half-Life & Pharmacokinetics
Variable depending on tissue context. Subject to proteolytic degradation but maintains activity in wound environments.
Reported Observations in Literature
As an endogenous peptide, generally well-tolerated at physiological concentrations. High concentrations can be cytotoxic to host cells in vitro. Research dosing focuses on staying within physiological ranges.
Key Research References
- Vandamme D, et al. “A comprehensive summary of LL-37, the factotum human cathelicidin peptide.” Cell Immunol. 2012