Recovery ⏱ Half-life: ~15-20 minutes (serum)

Thymulin

Facteur Thymique Sérique (FTS, Serum Thymic Factor)

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Half-Life
~15-20 minutes (serum)
Purity
≥98%
Mol. Weight
857.9 Da
Form
Lyophilized powder

What is Thymulin?

Thymulin is a nonapeptide hormone produced by thymic epithelial cells, discovered in the 1970s by Bach and colleagues. It is unique among thymic hormones in requiring zinc as a metallic cofactor, creating a direct link between zinc nutrition and immune competence. The age-related decline in thymulin mirrors immune aging, making it a biomarker and potential therapeutic target for immunosenescence.

Dosage Information (Research Use)

Research doses: 1-10μg/kg in animal studies. No standardized human protocol. Often studied in zinc-supplemented contexts. Research compound only.

Reconstitution & Handling

Reconstitute in sterile saline. Zinc must be present for biological activity.

Half-Life & Pharmacokinetics

~15-20 minutes (serum)

Reported Observations in Literature

Limited toxicity data. Well tolerated in animal studies. Zinc-dependent — excess zinc supplementation carries its own risks.

Key Research References

  • Bach JF. “Thymulin (FTS-Zn).” Clin Immunol Immunopathol. 1983;27:1-12
  • Reggiani PC et al. “Thymulin gene therapy.” Int Immunopharmacol. 2014;23:57-62

How Thymulin Works

Thymulin is the only thymic hormone with a fully characterized molecular structure. It requires zinc for biological activity — the Zn²⁺ ion stabilizes the peptide's active conformation. Thymulin promotes T-cell differentiation by inducing expression of T-cell markers (CD2, CD3, CD4, CD8) on immature thymocytes. It also modulates cytokine production and has demonstrated anti-inflammatory effects through HPA axis interaction.

Research Applications

🔬 Immunosenescence and aging
🔬 T-cell development and function
🔬 Autoimmune disease modulation

Research Findings

Thymulin levels decline dramatically with age, correlating with thymic involution. Zinc supplementation in elderly populations partially restores thymulin activity. Intranasal administration shows neuroprotective effects in demyelination models. Current research explores thymulin gene therapy for immune reconstitution.

Dosage & Administration

Research doses: 1-10μg/kg in animal studies. No standardized human protocol. Often studied in zinc-supplemented contexts. Research compound only.

Safety & Side Effects

Limited toxicity data. Well tolerated in animal studies. Zinc-dependent — excess zinc supplementation carries its own risks.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
Molecular Weight 857.9 Da
Half-Life ~15-20 minutes (serum)
Purity ≥98%
Form Lyophilized powder
Storage Lyophilized: -20°C. Reconstituted: 2-8°C, use within 24 hours.

Key Research References

  • Bach JF. "Thymulin (FTS-Zn)." Clin Immunol Immunopathol. 1983;27:1-12
  • Reggiani PC et al. "Thymulin gene therapy." Int Immunopharmacol. 2014;23:57-62

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