Lifestyle ⏱ Half-life: Approximately 5 minutes. FDA-Approved

Thyrotropin TRH

Thyrotropin-Releasing Hormone

Updated March 15, 2026

Evidence at a Glance

Regulatory statusFDA-Approved
Approved as protirelin (Thyrel/Relefact TRH), a pituitary-thyroid diagnostic; taltirelin approved in Japan.
Human evidenceExtensive
Animal evidenceExtensive

TRH (protirelin) is an FDA-approved injectable diagnostic used to assess pituitary-thyroid function, not a wellness, weight-loss, or cognitive-enhancement therapy.

What the research does not support

  • It is not an approved treatment for weight loss, mood, energy, or cognition; its only US approval is as a diagnostic test.
  • It does not treat hypothyroidism itself, it stimulates a TSH response to help diagnose thyroid or pituitary disorders.
  • The injectable diagnostic product has largely been discontinued in the US market.
  • Claims of neuroprotective or 'anti-aging' benefit are experimental and unproven in humans.
Half-Life
Approximately 5 minutes.
Mol. Weight
362.38 g/mol

What is Thyrotropin TRH?

TRH is the hypothalamic hormone that controls the thyroid axis — one of the most fundamental endocrine regulatory systems. Beyond thyroid stimulation, it has independent neuroactive properties including mood and arousal modulation.

Research Applications

Thyroid axis diagnostics, neuroendocrine research, mood modulation, arousal/consciousness studies, and pituitary function assessment.

Dosage Information (Research Use)

Diagnostic dose: 200-500 mcg IV bolus. Research doses vary. Research use only for non-clinical applications.

Reconstitution & Handling

Standard BAC water reconstitution.

Half-Life & Pharmacokinetics

Approximately 5 minutes.

Reported Observations in Literature

Transient urge to urinate, nausea, flushing, headache — all brief after IV bolus.

Key Research References

  • Gary KA, et al. “TRH test results in depression correlate with response to treatment.” Biol Psychiatry. 2003

How Thyrotropin TRH Works

TRH is a hypothalamic tripeptide that stimulates the anterior pituitary to release TSH (thyroid-stimulating hormone) and prolactin. It also has neuromodulatory effects including mood elevation, arousal, and anti-depressant-like activity independent of its thyroid axis effects.

Research Findings

Used clinically as a diagnostic tool for thyroid and pituitary function. Additional research interest in mood modulation, consciousness arousal, and neuroprotection.

Dosage & Administration

Diagnostic dose: 200-500 mcg IV bolus. Research doses vary. Research use only for non-clinical applications.

Safety & Side Effects

Transient urge to urinate, nausea, flushing, headache — all brief after IV bolus.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence pGlu-His-Pro-NH2
Molecular Weight 362.38 g/mol
Half-Life Approximately 5 minutes.
Available Sizes 2mg
Storage Lyophilized: -20°C. Reconstituted: 2-8°C.

Key Research References

  • Gary KA, et al. "TRH test results in depression correlate with response to treatment." Biol Psychiatry. 2003

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