Lifestyle ⏱ Half-life: Approximately 7.6 hours. FDA-Approved

Triptorelin

Triptorelin (GnRH Agonist)

Updated March 15, 2026

Evidence at a Glance

Regulatory statusFDA-Approved
Trelstar (palliative advanced prostate cancer) and Triptodur (pediatric central precocious puberty); GnRH receptor agonist
Human evidenceExtensive
Animal evidenceExtensive

A GnRH agonist FDA-approved for advanced prostate cancer and central precocious puberty that suppresses sex-hormone production after an initial hormonal flare.

What the research does not support

  • It is not a testosterone or fertility booster; it first causes a testosterone surge and then durably suppresses sex hormones.
  • It is not FDA-approved for bodybuilding 'post-cycle therapy,' a common off-label use lacking controlled evidence.
  • It does not restore fertility, and continued use can lower bone mineral density.
  • It is a physician-administered depot injection, not a benign self-dosed research peptide.
Half-Life
Approximately 7.6 hours.
Mol. Weight
1311.45 g/mol

What is Triptorelin?

Triptorelin is a potent synthetic GnRH agonist with well-established clinical applications. Its biphasic action — initial stimulation followed by sustained suppression — makes it useful in both activating and suppressing reproductive hormones depending on the protocol.

Research Applications

Gonadotropin modulation, hormone-dependent condition research, fertility protocols, and HPG axis reset studies.

Dosage Information (Research Use)

Single low-dose research use: 50-100 mcg as a single subcutaneous injection. Chronic use causes sustained suppression. Potent compound — research use only.

Reconstitution & Handling

Standard BAC water reconstitution. Very potent — precise dosing critical.

Half-Life & Pharmacokinetics

Approximately 7.6 hours.

Reported Observations in Literature

Initial testosterone/estrogen flare, followed by sustained suppression. Hot flashes, mood changes, bone density concerns with chronic use.

Key Research References

  • Huirne JA, Lambalk CB. “Gonadotropin-releasing-hormone-receptor antagonists.” Lancet. 2001

How Triptorelin Works

Triptorelin is a decapeptide GnRH agonist with ~100x the potency of native GnRH. Single-dose administration causes an initial surge of LH and FSH (flare effect), followed by receptor downregulation and sustained suppression of gonadotropin release with continued use.

Research Findings

Clinically used for prostate cancer, endometriosis, precocious puberty, and fertility protocols (controlled ovarian stimulation). In research, sometimes discussed for hormonal axis reset.

Dosage & Administration

Single low-dose research use: 50-100 mcg as a single subcutaneous injection. Chronic use causes sustained suppression. Potent compound — research use only.

Safety & Side Effects

Initial testosterone/estrogen flare, followed by sustained suppression. Hot flashes, mood changes, bone density concerns with chronic use.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Molecular Weight 1311.45 g/mol
Half-Life Approximately 7.6 hours.
Available Sizes 0.1mg, 2mg
Storage Lyophilized: -20°C. Reconstituted: 2-8°C.

Key Research References

  • Huirne JA, Lambalk CB. "Gonadotropin-releasing-hormone-receptor antagonists." Lancet. 2001

Related Peptides

View all →
SLU-PP-332
Lifestyle
SLU-PP-332 is a synthetic small molecule, not a peptide. It is an aryl acylhydrazone — 4-hydroxy-N’-[(E)-naphthalen-2-ylmethylidene]benzohydrazide, C18H14N2O2, molecular…
View Profile → Buy Now
Kisspeptin
Lifestyle
The master regulator of reproductive hormones — a 54-amino acid neuropeptide controlling GnRH release and fertility in both…
View Profile → Buy Now
Oxytocin
Lifestyle
Neuropeptide hormone researched for social bonding, anxiety reduction, stress physiology, and reproductive function.
View Profile → Buy Now