Lifestyle ⏱ Half-life: Approximately 1 hour.

Melanotan II

Melanotan II

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Half-Life
Approximately 1 hour.
Mol. Weight
1024.18 g/mol

What is Melanotan II?

Melanotan II is a synthetic analog of alpha-melanocyte stimulating hormone (α-MSH) developed for research into UV-protective tanning via melanogenesis. Its non-selective melanocortin receptor activity produces a range of effects beyond pigmentation.

Research Applications

Melanogenesis/photoprotection research, appetite regulation, melanocortin receptor pharmacology, and body composition studies.

Dosage Information (Research Use)

Research protocols: Loading phase of 250-500 mcg/day subcutaneously, with maintenance at reduced frequency. UV exposure typically required for visible pigmentation effects. Research use only.

Reconstitution & Handling

Standard BAC water reconstitution.

Half-Life & Pharmacokinetics

Approximately 1 hour.

Reported Observations in Literature

Nausea (common, especially initially), facial flushing, appetite suppression, spontaneous arousal effects, mole darkening (existing nevi), and fatigue. Regular dermatological monitoring recommended in research contexts.

Key Research References

  • Dorr RT, et al. “Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.” Life Sci. 1996

How Melanotan II Works

Melanotan II is a non-selective melanocortin receptor agonist (MC1R through MC5R). MC1R activation stimulates melanocyte melanin production (tanning). MC3R/MC4R activation in the hypothalamus affects appetite and sexual function. The broad receptor activity profile produces multiple simultaneous effects: increased pigmentation, appetite suppression, and enhanced libido.

Research Findings

Originally developed at University of Arizona for UV-protective tanning research. The sexual function side effect led to the development of PT-141 (which was refined for selective MC3R/MC4R activity). Extensively studied in dermatology contexts for photoprotective melanogenesis.

Dosage & Administration

Research protocols: Loading phase of 250-500 mcg/day subcutaneously, with maintenance at reduced frequency. UV exposure typically required for visible pigmentation effects. Research use only.

Safety & Side Effects

Nausea (common, especially initially), facial flushing, appetite suppression, spontaneous arousal effects, mole darkening (existing nevi), and fatigue. Regular dermatological monitoring recommended in research contexts.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Molecular Weight 1024.18 g/mol
Half-Life Approximately 1 hour.
Available Sizes 10mg
Storage Lyophilized: -20°C. Reconstituted: 2-8°C.

Key Research References

  • Dorr RT, et al. "Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study." Life Sci. 1996

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