Longevity ⏱ Half-life: Not fully characterized in published human pharmacokinetic data.

5-Amino-1MQ

5-Amino-1-Methylquinolinium

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Half-Life
Not fully characterized in published human pharmacokinetic data.
Mol. Weight
173.21 g/mol

What is 5-Amino-1MQ?

5-Amino-1MQ is a small molecule compound (not a peptide) that targets the NNMT enzyme — a recently identified regulator of fat cell metabolism and NAD+ homeostasis. It is commonly offered alongside peptide research compounds due to overlapping metabolic research applications.

Research Applications

NNMT inhibition research, adipose tissue metabolism, NAD+ salvage pathway, obesity models, and cellular energy expenditure studies.

Dosage Information (Research Use)

Animal model research: 2-10 mg/kg. Oral bioavailable compound. Research use only.

Reconstitution & Handling

N/A — orally bioavailable compound, typically supplied as capsules or powder.

Half-Life & Pharmacokinetics

Not fully characterized in published human pharmacokinetic data.

Reported Observations in Literature

Limited adverse effect data — primarily animal model studies. No significant toxicity reported at research doses in available literature.

Key Research References

  • Neelakantan H, et al. “Selective and membrane-permeable small molecule inhibitors of NNMT cause direct, rapid reductions in white adipose tissue.” Biochem J. 2018

How 5-Amino-1MQ Works

5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that metabolizes NAD+ precursors. By inhibiting NNMT, it increases intracellular NAD+ levels, activates the SAM (S-adenosylmethionine) cycle, and shifts fat cell metabolism from storage toward energy expenditure. NNMT is overexpressed in white adipose tissue in obesity, making it a specific metabolic target.

Research Findings

Preclinical data shows reduced fat cell size, increased cellular energy expenditure, and improved metabolic markers in diet-induced obesity models without affecting food intake. Represents a novel approach to metabolic research via the NNMT-NAD+ axis.

Dosage & Administration

Animal model research: 2-10 mg/kg. Oral bioavailable compound. Research use only.

Safety & Side Effects

Limited adverse effect data — primarily animal model studies. No significant toxicity reported at research doses in available literature.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence Non-peptide (small molecule NNMT inhibitor)
Molecular Weight 173.21 g/mol
Half-Life Not fully characterized in published human pharmacokinetic data.
Available Sizes 50mg capsules
Storage Room temperature, away from moisture and light.

Key Research References

  • Neelakantan H, et al. "Selective and membrane-permeable small molecule inhibitors of NNMT cause direct, rapid reductions in white adipose tissue." Biochem J. 2018

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