Growth ⏱ Half-life: Approximately 10-15 days due to Fc fusion technology.

ACE-031

ACE-031 (Soluble Activin Receptor Type IIB)

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Half-Life
Approximately 10-15 days due to Fc fusion technology.
Mol. Weight
~90,000 g/mol (fusion protein)

What is ACE-031?

ACE-031 represents a fundamentally different approach to myostatin inhibition — rather than blocking the ligand directly, it acts as a circulating trap that captures myostatin and related growth-limiting molecules before they can reach muscle tissue receptors.

Research Applications

Myostatin trap research, muscle wasting conditions, Duchenne muscular dystrophy, and lean mass augmentation studies.

Dosage Information (Research Use)

Clinical trial doses: 0.5-3 mg/kg subcutaneously every 2 weeks. Research use only.

Reconstitution & Handling

Reconstitute carefully with sterile water. Protein is sensitive to shaking.

Half-Life & Pharmacokinetics

Approximately 10-15 days due to Fc fusion technology.

Reported Observations in Literature

Clinical trials reported minor epistaxis (nosebleeds) and gingival bleeding, leading to study pause. Muscle efficacy was confirmed.

Key Research References

  • Attie KM, et al. “A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers.” Muscle Nerve. 2013

How ACE-031 Works

ACE-031 is a soluble form of the activin receptor type IIB fused to an IgG Fc domain. It acts as a decoy receptor, binding myostatin and activin in the bloodstream before they can signal muscle growth suppression. This creates a powerful pro-hypertrophy environment.

Research Findings

Showed significant lean mass increases in Phase II clinical trials for Duchenne muscular dystrophy. Development paused due to minor nosebleed and gum bleeding events, though muscle-building efficacy was confirmed.

Dosage & Administration

Clinical trial doses: 0.5-3 mg/kg subcutaneously every 2 weeks. Research use only.

Safety & Side Effects

Clinical trials reported minor epistaxis (nosebleeds) and gingival bleeding, leading to study pause. Muscle efficacy was confirmed.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence ActRIIB-Fc fusion protein
Molecular Weight ~90,000 g/mol (fusion protein)
Half-Life Approximately 10-15 days due to Fc fusion technology.
Available Sizes 1mg
Storage Lyophilized: -20°C. Reconstituted: 2-8°C, use within 7 days.

Key Research References

  • Attie KM, et al. "A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers." Muscle Nerve. 2013

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