Lifestyle ⏱ Half-life: Approximately 28 minutes (Kisspeptin-10 fragment).

Kisspeptin-10

Kisspeptin-10 (Metastin 45-54)

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Half-Life
Approximately 28 minutes (Kisspeptin-10 fragment).
Mol. Weight
1302.41 g/mol

What is Kisspeptin-10?

Kisspeptin-10 is the bioactive fragment of the kisspeptin neuropeptide system — discovered in 2003 as the master regulator of reproductive hormone signaling. It acts upstream of GnRH, making it the most fundamental trigger of the HPG axis.

Research Applications

Reproductive endocrinology, fertility research, GnRH neuron activation, LH secretion studies, and puberty onset research.

Dosage Information (Research Use)

Clinical research doses: 1-10 mcg/kg IV bolus or subcutaneous. Research use only.

Reconstitution & Handling

Standard BAC water reconstitution.

Half-Life & Pharmacokinetics

Approximately 28 minutes (Kisspeptin-10 fragment).

Reported Observations in Literature

Generally well-tolerated in clinical research. Flushing reported in some subjects.

Key Research References

  • Dhillo WS, et al. “Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males.” J Clin Endocrinol Metab. 2005

How Kisspeptin-10 Works

Kisspeptin acts on GPR54 (KISS1R) receptors on GnRH neurons in the hypothalamus, triggering GnRH release. This makes it the most upstream physiological trigger of the entire reproductive hormone cascade: Kisspeptin → GnRH → LH/FSH → Testosterone/Estrogen.

Research Findings

Potent, dose-dependent LH release documented in human clinical studies. Research interest in infertility, hypothalamic amenorrhea, and as a diagnostic tool for reproductive axis function.

Dosage & Administration

Clinical research doses: 1-10 mcg/kg IV bolus or subcutaneous. Research use only.

Safety & Side Effects

Generally well-tolerated in clinical research. Flushing reported in some subjects.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Molecular Weight 1302.41 g/mol
Half-Life Approximately 28 minutes (Kisspeptin-10 fragment).
Available Sizes 5mg
Storage Lyophilized: -20°C. Reconstituted: 2-8°C.

Key Research References

  • Dhillo WS, et al. "Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males." J Clin Endocrinol Metab. 2005

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