Lifestyle ⏱ Half-life: Approximately 30 minutes.

Melanotan I

Melanotan I (Afamelanotide)

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Half-Life
Approximately 30 minutes.
Mol. Weight
1646.85 g/mol

What is Melanotan I?

Melanotan I is the selective, linear melanocortin receptor agonist that produces UV-protective melanin production with a cleaner side-effect profile than its cyclic counterpart Melanotan II.

Research Applications

Photoprotective melanogenesis, EPP treatment, UV damage prevention research, and MC1R receptor pharmacology.

Dosage Information (Research Use)

Research protocols: 0.5-1 mg subcutaneously daily during loading, then maintenance. UV exposure required for visible effect. Research use only.

Reconstitution & Handling

Standard BAC water reconstitution.

Half-Life & Pharmacokinetics

Approximately 30 minutes.

Reported Observations in Literature

Nausea (common initially), facial flushing. Significantly fewer off-target effects than Melanotan II. Mole monitoring recommended.

Key Research References

  • Dorr RT, et al. “Effects of Melanotan I on melanin synthesis.” Photochem Photobiol. 2004

How Melanotan I Works

Melanotan I (afamelanotide) is a linear analog of alpha-MSH with preferential activity at the MC1R receptor on melanocytes. Unlike the cyclic Melanotan II which activates MC1R-MC5R broadly, Melanotan I is more selective, producing tanning effects with significantly reduced appetite, libido, and other off-target effects.

Research Findings

Approved in Europe (Scenesse) for erythropoietic protoporphyria (EPP). More selective and better-tolerated than Melanotan II. Produces gradual, natural-appearing pigmentation.

Dosage & Administration

Research protocols: 0.5-1 mg subcutaneously daily during loading, then maintenance. UV exposure required for visible effect. Research use only.

Safety & Side Effects

Nausea (common initially), facial flushing. Significantly fewer off-target effects than Melanotan II. Mole monitoring recommended.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence [Nle4, D-Phe7]-α-MSH (linear 13-amino acid)
Molecular Weight 1646.85 g/mol
Half-Life Approximately 30 minutes.
Available Sizes 10mg
Storage Lyophilized: -20°C. Reconstituted: 2-8°C.

Key Research References

  • Dorr RT, et al. "Effects of Melanotan I on melanin synthesis." Photochem Photobiol. 2004

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