Cognitive ⏱ Half-life: Short. Experimental

Cortagen

Cortagen (AEDP Peptide)

Updated March 15, 2026

Evidence at a Glance

Regulatory statusExperimental
Khavinson cerebral-cortex tetrapeptide; registered in Russia as a bioregulator, no FDA/EMA/MHRA approval; research chemical elsewhere.
Human evidenceLimited
Animal evidenceModerate

Rodent nerve-regeneration and geroprotective studies exist mostly from the Khavinson/Anisimov groups, with only small Russian clinical reports and no independent Western randomized trials.

What the research does not support

  • It is not approved by the FDA, EMA, or MHRA and is sold as a research chemical.
  • Evidence is limited to Russian/CIS animal and small clinical studies, without independent RCTs.
  • Its DNA/gene-regulation mechanism is a hypothesis, not confirmed in humans.
  • It is not proven to enhance cognition, repair nerves, or extend lifespan in people.
Half-Life
Short.
Mol. Weight
~431 g/mol

What is Cortagen?

Cortagen is a synthetic peptide bioregulator designed to support brain cortical tissue and neuroimmune function.

Research Applications

Cortical neuroprotection, cognitive decline research, neuroinflammation, and brain aging models.

Dosage Information (Research Use)

10-20 mg/day for 10-30 day courses. Research use only.

Reconstitution & Handling

Standard.

Half-Life & Pharmacokinetics

Short.

Reported Observations in Literature

Generally well-tolerated.

Key Research References

  • Khavinson VK. “Peptide Bioregulators.” 2003

How Cortagen Works

Cortagen targets gene expression in cortical neurons, supporting neuroimmune balance, antioxidant defense, and cognitive function maintenance.

Research Findings

Studied for cognitive decline, neuroinflammation, and cortical neuroprotection.

Dosage & Administration

10-20 mg/day for 10-30 day courses. Research use only.

Safety & Side Effects

Generally well-tolerated.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence Ala-Glu-Asp-Pro
Molecular Weight ~431 g/mol
Half-Life Short.
Available Sizes 5mg
Storage Lyophilized: -20°C.

Key Research References

  • Khavinson VK. "Peptide Bioregulators." 2003

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