Lifestyle ⏱ Half-life: Approximately 2-4 minutes. Very short, mimicking the natural pulsatile GnRH release pattern.

Gonadorelin

Gonadorelin (GnRH)

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Half-Life
Approximately 2-4 minutes. Very short, mimicking the natural pulsatile GnRH release pattern.
Mol. Weight
1182.29 g/mol

What is Gonadorelin?

Gonadorelin is the synthetic form of the hypothalamic hormone GnRH — the master regulator of reproductive hormone signaling. It sits at the top of the hypothalamic-pituitary-gonadal axis and controls the release of LH and FSH.

Research Applications

HPG axis maintenance, fertility research, pituitary function diagnostics, LH/FSH stimulation, and testosterone production support research.

Dosage Information (Research Use)

Research protocols: 100-250 mcg subcutaneously, 2-3 times weekly. Pulsatile dosing preferred. Research use only.

Reconstitution & Handling

Standard BAC water reconstitution.

Half-Life & Pharmacokinetics

Approximately 2-4 minutes. Very short, mimicking the natural pulsatile GnRH release pattern.

Reported Observations in Literature

Generally well-tolerated. Headache, injection site reactions. Continuous (non-pulsatile) administration causes paradoxical suppression of LH/FSH.

Key Research References

  • Conn PM, Crowley WF. “Gonadotropin-releasing hormone and its analogs.” Annu Rev Med. 1994

How Gonadorelin Works

Gonadorelin is a synthetic version of the naturally occurring gonadotropin-releasing hormone (GnRH). When administered in pulsatile fashion, it stimulates the anterior pituitary to release LH (luteinizing hormone) and FSH (follicle-stimulating hormone), maintaining or restoring normal reproductive axis function.

Research Findings

Used clinically as a diagnostic tool for pituitary function. In research, commonly studied for maintaining endogenous testosterone production during protocols that might suppress the HPG axis.

Dosage & Administration

Research protocols: 100-250 mcg subcutaneously, 2-3 times weekly. Pulsatile dosing preferred. Research use only.

Safety & Side Effects

Generally well-tolerated. Headache, injection site reactions. Continuous (non-pulsatile) administration causes paradoxical suppression of LH/FSH.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Molecular Weight 1182.29 g/mol
Half-Life Approximately 2-4 minutes. Very short, mimicking the natural pulsatile GnRH release pattern.
Available Sizes 2mg
Storage Lyophilized: -20°C. Reconstituted: 2-8°C.

Key Research References

  • Conn PM, Crowley WF. "Gonadotropin-releasing hormone and its analogs." Annu Rev Med. 1994

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