Lifestyle ⏱ Half-life: ~4 minutes (IV); ~27 minutes (SC)

Kisspeptin

Kisspeptin-54 (Metastin, KISS1 Gene Product)

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Half-Life
~4 minutes (IV); ~27 minutes (SC)
Purity
≥98%
Mol. Weight
5,847.7 Da
Form
Lyophilized powder

What is Kisspeptin?

Kisspeptin-54 is the full-length active form of the KISS1 gene product, representing the most important discovery in reproductive neuroendocrinology in decades. It sits at the top of the reproductive hormone cascade, making it a unique therapeutic target for fertility disorders that avoids the receptor desensitization problems of GnRH analogs.

Dosage Information (Research Use)

Research/IVF: 6.4-12.8 nmol/kg SC or IV bolus. For oocyte maturation: single SC dose 36 hours before retrieval. Clinical research compound — not commercially available as a therapeutic.

Reconstitution & Handling

Reconstitute in sterile saline.

Half-Life & Pharmacokinetics

~4 minutes (IV); ~27 minutes (SC)

Reported Observations in Literature

Generally well tolerated in clinical studies. Mild injection site reactions. Transient flushing. No OHSS reported when used as IVF trigger (major safety advantage over hCG).

Key Research References

  • Dhillo WS et al. “Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males.” J Clin Endocrinol Metab. 2005;90:6609-15
  • Abbara A et al. “Kisspeptin as a trigger for oocyte maturation in IVF.” N Engl J Med. 2017;376:1975-6

How Kisspeptin Works

Kisspeptin-54 (the full-length form) activates the kisspeptin receptor (KISS1R/GPR54) on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This is the primary physiological mechanism initiating puberty and maintaining reproductive function. Unlike GnRH analogs, kisspeptin acts upstream, producing a more physiological pattern of gonadotropin release. It also acts as a metastasis suppressor in some cancers (hence the name "Metastin").

Research Applications

🔬 Female infertility and IVF
🔬 Male hypogonadism
🔬 Functional hypothalamic amenorrhea

Research Findings

IV kisspeptin-54 potently stimulates LH release in both sexes. In IVF, kisspeptin replaces hCG as an oocyte maturation trigger with dramatically lower risk of ovarian hyperstimulation syndrome (OHSS). Studies in functional hypothalamic amenorrhea show restoration of LH pulsatility. Shorter fragments (kisspeptin-10) retain receptor binding but have shorter duration.

Dosage & Administration

Research/IVF: 6.4-12.8 nmol/kg SC or IV bolus. For oocyte maturation: single SC dose 36 hours before retrieval. Clinical research compound — not commercially available as a therapeutic.

Safety & Side Effects

Generally well tolerated in clinical studies. Mild injection site reactions. Transient flushing. No OHSS reported when used as IVF trigger (major safety advantage over hCG).

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Molecular Weight 5,847.7 Da
Half-Life ~4 minutes (IV); ~27 minutes (SC)
Purity ≥98%
Form Lyophilized powder
Storage Lyophilized: -20°C.

Key Research References

  • Dhillo WS et al. "Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males." J Clin Endocrinol Metab. 2005;90:6609-15
  • Abbara A et al. "Kisspeptin as a trigger for oocyte maturation in IVF." N Engl J Med. 2017;376:1975-6

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