Cognitive ⏱ Half-life: 20-30 minutes (plasma)

Neuropeptide Y

Neuropeptide Y (NPY)

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Half-Life
20-30 minutes (plasma)
Purity
≥95%
Mol. Weight
4,253.69 Da
Form
Lyophilized powder

What is Neuropeptide Y?

Neuropeptide Y is a 36-amino acid neuropeptide that is among the most abundant peptides in the mammalian nervous system. It plays central roles in appetite regulation, stress response, anxiety modulation, and circadian rhythm maintenance. Research interest spans from obesity (as the brain’s primary hunger signal) to military stress resilience and PTSD treatment.

Dosage Information (Research Use)

Intranasal: 2.4-9.6mg per dose in human studies. Research typically uses central injection in animal models. Research compound only.

Reconstitution & Handling

Reconstitute in sterile saline. Sensitive to proteolysis — handle carefully.

Half-Life & Pharmacokinetics

20-30 minutes (plasma)

Reported Observations in Literature

Increased appetite is the primary expected effect. Potential cardiovascular effects (vasoconstriction). Sedation at high doses. Anxiety reduction in stressed subjects.

Key Research References

  • Morgan CA et al. “Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress.” Biol Psychiatry. 2002;52:136-42
  • Sah R et al. “Neuropeptide Y and posttraumatic stress disorder.” Mol Psychiatry. 2009;14:954-8

How Neuropeptide Y Works

NPY acts through five receptor subtypes (Y1-Y5). Y1 and Y5 receptors mediate orexigenic (appetite-stimulating) effects and anxiolytic properties. Y2 receptors serve as presynaptic autoreceptors that inhibit further NPY release. NPY is the most potent orexigenic substance known — central injection produces intense feeding behavior. It also inhibits the HPA stress axis, providing stress resilience and anxiolytic effects.

Research Applications

🔬 Obesity and metabolic syndrome
🔬 Anxiety disorders and PTSD
🔬 Stress resilience mechanisms

Research Findings

Military studies show that soldiers with higher baseline NPY levels demonstrate greater stress resilience. Special forces trainees have higher NPY responses than controls. NPY Y1 receptor agonists are under development as anxiolytics. Intranasal NPY shows promise for PTSD in early clinical studies.

Dosage & Administration

Intranasal: 2.4-9.6mg per dose in human studies. Research typically uses central injection in animal models. Research compound only.

Safety & Side Effects

Increased appetite is the primary expected effect. Potential cardiovascular effects (vasoconstriction). Sedation at high doses. Anxiety reduction in stressed subjects.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Molecular Weight 4,253.69 Da
Half-Life 20-30 minutes (plasma)
Purity ≥95%
Form Lyophilized powder
Storage Lyophilized: -20°C. Reconstituted: 2-8°C.

Key Research References

  • Morgan CA et al. "Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress." Biol Psychiatry. 2002;52:136-42
  • Sah R et al. "Neuropeptide Y and posttraumatic stress disorder." Mol Psychiatry. 2009;14:954-8

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