PE-22-28 represents a novel approach to mood research — targeting TREK-1 potassium channels rather than traditional monoamine pathways. Early animal data suggests rapid-onset effects, distinguishing it from conventional approaches that require weeks.
Research Applications
TREK-1 channel research, rapid-onset mood modulation, serotonergic signaling, hippocampal neurogenesis, and stress resilience models.
Dosage Information (Research Use)
Animal research: 100-500 mcg/kg intranasal or IV. Human dosing not established. Research use only.
Reconstitution & Handling
Standard BAC water reconstitution.
Half-Life & Pharmacokinetics
Not well characterized.
Reported Observations in Literature
Limited data — primarily animal studies. Potassium channel modulation requires careful research protocol design.
Key Research References
- Moha ou Maati H, et al. “The peptidic antidepressant spadin interacts with prefrontal 5-HT4 and mGluR2 receptors.” Brain Struct Funct. 2016