Recovery ⏱ Half-life: ~30-60 minutes Approved Abroad

Thymopentin

Thymopentin (TP-5, Timunox)

Updated March 30, 2026

Evidence at a Glance

Regulatory statusApproved Abroad
Synthetic thymopoietin fragment (TP-5); used clinically in China and formerly Europe (Timunox); not FDA-approved.
Human evidenceModerate
Animal evidenceExtensive

Thymopentin (TP-5) is a synthetic thymic pentapeptide used clinically abroad for immunodeficiency and studied in rheumatoid arthritis and hepatitis B, but its trials are older and its very short half-life limits practical use.

What the research does not support

  • It is not FDA-approved for any indication in the United States.
  • It has an extremely short in-vivo half-life, requiring frequent injection and limiting real-world efficacy.
  • It is not a proven treatment for general 'immune boosting' in otherwise healthy people.
  • Human trial results in rheumatoid arthritis and HIV were mixed and are decades old.
Half-Life
~30-60 minutes
Purity
≥98%
Mol. Weight
679.77 Da
Form
Lyophilized powder

What is Thymopentin?

Thymopentin is a synthetic pentapeptide that captures the immune-modulating activity of the full thymopoietin molecule in just five amino acids. It has been used clinically in several countries for decades, primarily in China where it is approved for immunodeficiency states, chronic infections, and as supportive therapy in cancer treatment.

Dosage Information (Research Use)

Clinical doses: 1mg IM or SC, 3x weekly for 4-12 weeks. Some protocols use 50mg IV. Available as pharmaceutical product in select markets.

Reconstitution & Handling

Reconstitute lyophilized powder in sterile water for injection.

Half-Life & Pharmacokinetics

~30-60 minutes

Reported Observations in Literature

Generally well tolerated. Mild injection site reactions, occasional transient fever (1-2%), rare allergic reactions. No significant organ toxicity reported in clinical use.

Key Research References

  • Goldstein G et al. “Thymopentin and the immune system.” Thymus. 1987;10:37-46

How Thymopentin Works

Thymopentin represents the minimal active sequence (positions 32-36) of thymopoietin, a 49-amino acid thymic hormone. It induces differentiation of bone marrow precursor cells into T-lymphocytes and modulates the balance between T-helper and T-suppressor populations. It enhances IL-2 production and NK cell activity while having immunomodulatory rather than immunostimulatory effects.

Research Applications

🔬 Primary immunodeficiency
🔬 HIV/AIDS immune support
🔬 Cancer immunotherapy adjunct

Research Findings

Clinical studies show enhanced T-cell counts in immunodeficient patients. Used clinically in China and parts of Europe for chronic hepatitis B, post-surgical immune recovery, and as an immunotherapy adjunct. Over 100 clinical trials registered.

Dosage & Administration

Clinical doses: 1mg IM or SC, 3x weekly for 4-12 weeks. Some protocols use 50mg IV. Available as pharmaceutical product in select markets.

Safety & Side Effects

Generally well tolerated. Mild injection site reactions, occasional transient fever (1-2%), rare allergic reactions. No significant organ toxicity reported in clinical use.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence Arg-Lys-Asp-Val-Tyr
Molecular Weight 679.77 Da
Half-Life ~30-60 minutes
Purity ≥98%
Form Lyophilized powder
Storage Lyophilized: 2-8°C. Reconstituted: use immediately.

Key Research References

  • Goldstein G et al. "Thymopentin and the immune system." Thymus. 1987;10:37-46

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