Skin ⏱ Half-life: Variable by delivery method. Preclinical

PTD-DBM

PTD-DBM (Protein Transduction Domain-Dishevelled Binding Motif)

Updated March 15, 2026

Evidence at a Glance

Regulatory statusPreclinical
Investigational CXXC5/Dishevelled-disrupting Wnt activator; animal and in-vitro data only, no human trials.
Human evidenceNone
Animal evidenceLimited

An experimental peptide that activates Wnt/beta-catenin signaling and induced hair regrowth in mice in a 2017 Yonsei study, but has never been tested in humans.

What the research does not support

  • It has not been tested in humans; all hair-growth evidence comes from mouse models and cell cultures.
  • It is not an FDA-approved or clinically validated baldness treatment.
  • It has never been shown to match or beat minoxidil or finasteride in any human study.
  • Regrowth claims rest largely on a single animal study and lack large-scale independent replication.
Half-Life
Variable by delivery method.
Mol. Weight
~2400 g/mol

What is PTD-DBM?

PTD-DBM is a cell-penetrating peptide designed to activate the Wnt signaling pathway in hair follicle dermal papilla cells. The Wnt pathway is essential for hair follicle formation and cycling, making it a key target in hair loss research.

Research Applications

Hair follicle regeneration, Wnt pathway activation, alopecia research, and dermal papilla cell biology.

Dosage Information (Research Use)

Primarily topical or intradermal injection in research. Doses vary by model. Research use only.

Reconstitution & Handling

Standard BAC water reconstitution.

Half-Life & Pharmacokinetics

Variable by delivery method.

Reported Observations in Literature

Limited data. Local application reduces systemic concerns.

Key Research References

  • Kwack MH, et al. “A cell-penetrating peptide activates Wnt signaling and induces hair regrowth.” Sci Rep. 2017

How PTD-DBM Works

PTD-DBM activates the Wnt/β-catenin signaling pathway by stabilizing β-catenin through inhibition of its phosphorylation and degradation. In hair follicles, Wnt pathway activation promotes dermal papilla cell proliferation and new hair follicle neogenesis. The PTD (protein transduction domain) enables cell membrane penetration.

Research Findings

Published research in mice showed restoration of hair growth in alopecia models. Represents a peptide-based approach to hair regeneration through a well-validated molecular pathway.

Dosage & Administration

Primarily topical or intradermal injection in research. Doses vary by model. Research use only.

Safety & Side Effects

Limited data. Local application reduces systemic concerns.

Important: All safety information is derived from published research, primarily animal studies. No controlled human clinical trial data exists unless explicitly noted. This compound is sold for research purposes only.

Quick Facts

Sequence Cell-penetrating peptide fused to Dvl-binding domain
Molecular Weight ~2400 g/mol
Half-Life Variable by delivery method.
Available Sizes 5mg
Storage Lyophilized: -20°C. Reconstituted: 2-8°C.

Key Research References

  • Kwack MH, et al. "A cell-penetrating peptide activates Wnt signaling and induces hair regrowth." Sci Rep. 2017

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