GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring peptide-copper complex found in human plasma. It declines significantly with age — from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60 — correlating with reduced regenerative capacity.
Research Applications
Wound healing, skin aging and remodeling, collagen synthesis, hair growth, gene expression modulation, tissue regeneration, and systemic anti-aging research.
Dosage Information (Research Use)
Topical: various concentrations in creams/serums. Subcutaneous research: 1-3 mg/day in protocols documented in literature. Research use only.
Reconstitution & Handling
Reconstitute with BAC water. The blue/green color of the solution is normal and indicates active copper complex. Protect from light.
Half-Life & Pharmacokinetics
Short plasma half-life, but tissue-level effects persist due to gene expression modulation and ECM remodeling cascades.
Reported Observations in Literature
Generally well-tolerated topically and subcutaneously. Copper is an essential trace element but excessive systemic copper should be monitored.
Key Research References
- Pickart L, et al. “GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.” Biomed Res Int. 2015
- Pickart L, Margolina A. “Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.” Int J Mol Sci. 2018